William A. Ziehler, Ph.D.

William A. Ziehler, Ph.D.419-365-2065 (Direct)
419-874-1100 (Office)
419-874-1130 (Fax)
E-Mail: ziehler@fraser-ip.com

Dr. Ziehler’s legal practice focuses on the drafting and prosecution of chemical, biochemical, and biomedical patent applications. He also prepares freedom-to-operate opinions and prior art searches in the chemical arts and life sciences.

Dr. Ziehler’s graduate thesis focused on biochemical, biophysical, and genetic studies of nucleic acid and protein interactions, in particular those involved in catalytic RNA enzymes. Thereafter he worked at a biotechnology company where he contributed to the development of a novel means of whole genome amplification, including unique nucleic acid manipulations, which culminated in a pending U.S. patent application.

Dr. Ziehler has experience managing corporate research projects and developing and instituting corporate IP management policies. He has also taught undergraduate biochemistry courses.

– J.D., magna cum laude, Michigan State University, with a concentration in Intellectual Property Law
– Ph.D. in Biological Chemistry, University of Michigan
– B.S. in Biochemistry, Case Western Reserve University

Honors & Distinctions
– Cellular Biotechnology Training Grant, funded by the National Institutes of Health
– Rackham Pre-Doctoral Fellowship at the University of Michigan

Bar Admissions
– State of Michigan
– U.S. District Court for the Eastern District of Michigan
– U.S. Patent and Trademark Office


Pinter J, Kurihara T, Sleptsova I, Bruening E, Ziehler W, Makarov V (October 21, 2004) In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA. United States Patent Application Publication No. 20040209299; and PCT Publication No. WO/2004/081183.

Barker DL, Hansen MST, Faruqi FA, Giannola D, Irsula OR, Lasken RS, Latterich M, Makarov V, Oliphant A, Pinter JH, Shen R, Sleptsova I, Ziehler W, and Lai E (2004). Two Methods of Whole Genome Amplification Enable Accurate Genotyping across a 2,320-SNP Linkage Panel. Genome Research 14(5):901-7.

Kamberov K, Sleptsova I, Suchyta S, Bruening E, Ziehler W, Seward Nagel J, Langmore J, Makarov V (2002). Use of In Vitro OmniPlex Libraries for High-Throughput Comparative Genomics and Molecular Haplotyping. Proceedings of SPIE 4646:340-351.

Houser-Scott F, Ziehler WA, Engelke DR. (2001) Saccharomyces cerevisiae nuclear ribonuclease P: structure and function. Methods Enzymol. 342:101-17.

Ziehler WA, Morris J, Scott F, Millikin C, and Engelke DR (2001). An essential protein-binding domain of nuclear RNase P RNA. RNA 7:565-575.

Ziehler WA, Day JJ, Fierke CA, and Engelke DR (2000). Effects of 5’ Leader and 3’ Trailer Structures on pre-tRNA Processing by Nuclear RNase P. Biochemistry 39:9909-9916.

Ziehler WA and Engelke DR (2000). Probing RNA structure with chemical reagents and enzymes. Current Protocols in Nucleic Acid Chemistry, Chapter 6.1, John Wiley & Sons, Inc., New York, N.Y.

Ziehler WA, Yang J, Kurochkin AV, Sandusky PO, Zuiderwig ERP, and Engelke DR (1998). Structural Analysis of the P10/11-P12 RNA Domain of Yeast RNase P RNA and Its Interaction with Magnesium. Biochemistry 37:3549-3557.

Ziehler WA, Lee Y, Pagan-Ramos E, and Engelke DR (1997). An active domain of the nuclear RNase P RNA. Nucleic Acids Symposium Series 36:45-48.

Ziehler WA and Engelke DR (1996). Synthesis of Small RNA Transcripts with Discrete 5’ and 3’ Ends. Biotechniques 20:622-624.

Conference Abstracts

Houser-Scott F, Ziehler WA, Millikin C, Xiao S, and Engelke DR (2000). The Complexity of Nuclear RNase P. RNA 2000. Madison, Wisconsin.

Ziehler WA and Engelke DR (1997). Investigation of the P10/11-P12 RNA Domain of Yeast Nuclear RNase P RNA and Its Interaction with Magnesium. RNA ’97, Second Annual Meeting of the RNA Society. Banff, Alberta, Canada.

Ziehler WA, Pagan-Ramos E, Tranguch AJ, and Engelke DR (1996). Investigation of RNA Subdomains of the RNA Component of Yeast Nuclear RNase P and Synthesis of Small RNA Transcripts with Discrete 5’ and 3’ Ends. RNA ’96, First Annual Meeting of the RNA Society. Madison, Wisconsin.

Ziehler WA and Engelke DR (1995). Synthesis of Small RNA Transcripts with Discrete 5’ and 3’ Ends. Indiana Molecular Biology Symposium IX – The Exploration of Sequence Space: Selecting Functional Molecules from Combinatorial Libraries. Bloomington, Indiana.

Gupta-Bansal R, Ziehler W, Wujek JR, Brunden KR (1993). Potential role of proteoglycans in the accumulation and persistence of beta-amyloid (Ab) in Alzheimer’s disease (AD) senile plaques. Society for Neuroscience Abstracts 19:1471.